Frumil (Amiloride)

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"Generic Frumil"
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Frumil (Amiloride)
TAKING CARE OF YOUR HEART: SMOKING AND THE ARTERIES
It has been claimed that almost a quarter of the 157,000 Britons who die of heart attack each year develop the disease chiefly because they are smokers. More than half of a smoker’s increased risk of dying is due to heart disease and stroke. People who have had a heart attack are much more likely to have a second one if they continue to smoke. And attacks of pain due to coronary disease (angina) occur more frequently in smokers.
Not only the coronary arteries but also those supplying the brain and lower limbs are affected by cigarette smoking. This can lead to one form of stroke. Narrowing of the arteries to the legs can result in gangrene, or may cause disabling attacks of pain in the legs on walking a short distance (intermittent claudication). In a hospital ward where patients with this condition are treated, one is likely to see a well-filled ashtray by every bed.
A few years ago a young woman came to the clinic with the complaint that she developed severe pain in both calves when she walked: she could manage no more than a hundred yards. She had impaired blood flow to the legs, confirmed by X-rays, and the diagnosis of intermittent claudication was made. It was due to atherosclerosis of the lower aorta. This is very uncommon in women of her age. She was found to have very high levels of blood cholesterol and triglyceride; this was corrected by weight reduction and a drug. She was advised to stop smoking, but could not give it up. Her circulation problem remained static for years. Finally she succeeded in giving up cigarettes. Within weeks of stopping smoking she became able to walk much more freely, having pain only when she hurried or climbed a steep hill. Her arterial disease was clearly related to her inherited high cholesterol state; but most of her improvement happened when she stopped smoking.
Another arterial disease which is many times commoner in smokers is aneurysm of the aorta. The main artery of the trunk, weakened by atherosclerosis, develops a ‘blow-out’ like a damaged tyre. If detected in time, it can be dealt with surgically; untreated it may lead to grave or fatal consequences.
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