Archive for the ‘Cancer’ Category

Rheumatrex (Methotrexate)

Tuesday, November 3rd, 2009


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Rheumatrex (Methotrexate)
CHEMICAL SUNSCREENS TO PREVENT SKIN CANCER
There has been an explosion in the number and variety of sunscreens available from pharmacies and supermarkets over the last ten years. These invisible sunscreens provide good protection from ultraviolet ’ light but generally only moderate protection from ultraviolet A light. Nonetheless, consistent use will lower your chances of developing skin cancer and will allow your skin to repair some of the damage caused by the sun.
Chemical sunscreens work by absorbing ultraviolet light, preventing penetration into the skin’s deeper layers. They must be applied at least twenty minutes before sun exposure so that they can bind to the skin. They should also be at least factor 15; lower factor sunscreens are much less effective. On the other hand, sunscreens greater than factor 15 provide little added protection and increase the risk of allergic reactions.
Despite the popularity and improved cosmetic appearance of the newer sunscreens, they do have significant limitations:
- Sunscreens tend to lose their effectiveness after two hours, especially outdoors. They need to be re-applied frequently while outside, but can be applied less often in shaded areas.
- Sunscreens wash off when sweating and swimming, so they must be re-applied frequently during sporting activities and after swimming. If they drip into the eyes with sweat they can cause burning and stinging.
- All the invisible ‘rub in’ chemical sunscreens give relatively poor protection from ultraviolet A light. This means your skin can still age from sun exposure and may develop pigmentation and freckling.
- Many sunscreens, especially the waterproof varieties, are greasy and so can aggravate or cause acne and blemishes on the face. It is best to use a milky or gel sunscreen on the face. A milky sunscreen such as Ego SunSense Toddler Milk, Clinique City Block or Roche Aquababy is particularly good for women and is suitable for use on a daily basis. It can be applied over a moisturizer and then foundation can be applied on top. Some people prefer alcohol-based sunscreens such as Clinique Oil-Free Sun Block SPF 15+, Ella Bache Great Sports Gel SPF 15+, Hamilton SPF 15 alcohol spray and Koala Beach SPF 15 gel.
- Sunscreens contain various chemicals which can irritate the skin and eyes. Generally speaking, the higher the concentration of sunscreen chemicals, the more likely it is that an irritation will develop. The newer sunscreens have a lower concentration of sunscreen chemicals and a higher concentration of physical sunscreens, such as titanium dioxide, which are less irritating, have a broader spectrum of action and cut out a substantial amount of ultraviolet A light. Apart from skin cancer protection, they also provide better protection from premature ageing. They leave a whitish film on the skin, however, which looks unattractive. Hopefully future formulas will be flesh-coloured. Currently available preparations include Clinique City Block, Ego SunSense, Ego Sunsensitive, ICI Solazone and UV Low Allergenic Formula.
- All the ingredients in sunscreens except titanium dioxide can cause allergic reactions. Because cosmetics manufacturers are now incorporating sunscreens routinely into their formulas we will undoubtedly see an increase in the number of sunscreen allergies.
- The long-term safety of sunscreens has still not been well established. Overall, the benefits seem to outweigh the risks, but there are really no good studies which confidently prove their lack of adverse effects, especially in children.
CancerThere has been some publicity recently which linked the use of sunscreens with skin cancer. This
was based on an old study which has since been shown to be untrue.
*6/150/58*

Vepesid (Etoposide)

Tuesday, November 3rd, 2009


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Vepesid (Etoposide)
PROTECTING OURSELVES FROM SKIN CANCER
What does SPF mean?
Many people are confused about SPF labeling. SPF means ‘Sun Protection Factor’ and relates only to a sunscreen’s ability to protect from sunburn. It does not imply protection from ageing, freckling or tanning, but does imply protection from skin cancer.
An SPF factor 15 sunscreen will allow you to spend fifteen times as long in the sun without getting sun-burnt. So, if at midday it takes only half an hour to become sun-burnt, wearing an SPF factor 15 sunscreen will allow you to stay in the sun for seven and a half hours without getting burnt. An SPF 40 sunscreen would allow you to stay in the sun for twenty hours without getting burnt, but of course a factor 40 sunscreen would be pointless because the sun doesn’t shine for a straight twenty hours. It must also be remembered that sunscreens are tested in indoor conditions, and how this translates to outdoor conditions is really unknown.
Chemicals in sunscreens
Traditional sunscreens contain PABA (Amino Benzoic Acid). Because this caused a significant number of allergic reactions other chemicals have now largely replaced it. These include benzophenone, butyl methoxydibenzoylmethane, cinnamates and titanium dioxide.
There are several new and exciting developments in the sunscreen field. One company is investigating the possible use of ‘natural’ sunscreens derived from coral. Coral is able to protect itself from sunlight by secreting a substance which coats its outer surface. If this can be successfully extracted and is found to be safe in humans, it may prove a good alternative to the currently available preparations.
Solariums
Many solariums advertise the promise of a safe tan, and promote the notion that if one regularly uses a solarium one is less likely to develop sunburn. But there is no such thing as a safe tan. Any tanning of the skin is an indicator of sun damage and of increased skin cancer risk.
Because solariums contain a higher percentage of ultraviolet A light, they lead to premature ageing of the skin and abnormal pigmentation – a high price to pay for a so-called ‘healthy’ tan. At the present time there is nothing to recommend solarium use, except for people with psoriasis.
Fake tans
These creams contain a chemical called dihydroxyacetone which colours the skin brown. They appear to be safe and non-damaging to the skin, and are certainly preferable to sunbathing or using a solarium. They do protect the skin from ultraviolet light to some extent but should not be used as a substitute for a sunscreen. Clarins, Ella Bache and Lancome all make good products.
Some fake tans were withdrawn from the market because they contained urocanic acid which was shown to promote skin cancer in animals. Since urocanic acid is not an essential ingredient, it is no longer used in these creams.
*7/150/5*

Alkeran (Melphalan)

Tuesday, November 3rd, 2009


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Alkeran (Melphalan)
COLORECTAL CANCER
The incidence of colorectal cancer in western countries ranks second only to cancer of the lung. It is unusual to see this malignancy before the age of 40 in both men and women and the incidence reaches its peak between the ages of 75 and 80 years. 50 per cent of large bowel malignancies occur within 12 inches of the anus. The most common presentation in such instances is the passage of blood with the bowel motions. In spite of the presence of hemorrhoids, a doctor must check for cancer of the colon in all cases of anal bleeding. It is worth repeating “If a doctor doesn’t put his finger in it, he puts his foot in it”.
Surgery is still the mainstay of colorectal cancer treatment. Radiotherapy has a growing role and anticancer drugs have yet to prove a spectacular success. Survival from colorectal cancer depends on the extent to which the cancer has spread before therapeutic intervention. Almost 80 percent of colorectal cancer victims will survive, if the cancer limits itself to the inside of the bowel wall at operation. This percentage falls as the tumour spreads through the bowel into the lymphatic system, the venous circulation and the peritoneal cavity outside the bowel walls.
Current opinion favours the argument that nearly all forms of bowel cancer start as small growths on the inner surface of the bowel wall. The promising implication of this point of view is that deaths from cancer of the colon are entirely preventable – if investigation and diagnosis take place early enough. The question as to what age constitutes the first time everybody in western society needs to undergo their initial screening colonoscopy remains unanswered.
Home Remedies
A high incidence of colorectal cancer occurs in societies where high fat, low fibre diets are prevalent. One study has found a positive association between high cholesterol and colorectal cancer. Another report found that a higher frequency of pre malignant growths in the colon correlated with a high serum cholesterol.
A low fibre intake makes two contributions to cancer of the large bowel. Firstly, a low faecal bulk means cancer forming chemicals reach higher concentrations in contact with the inner bowel wall. Secondly, it means that cancer forming chemicals travel through the bowel slowly.
High fibre, low cholesterol diets not only protect from heart disease and cancer of the breast but they also protect from cancer of the colon as well.
*4/131/5*

Nolvadex (Tamoxifen)

Tuesday, November 3rd, 2009


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Nolvadex (Tamoxifen)
SKIN CANCERS AND HOME REMEDIES
Pale skin in this society is widely and mistakenly associated with the presence of ill health. As far as skin cancer is concerned, the sun bronzed Aussie is a walking recipe for dermatological disaster.
Ultraviolet rays from the sun are now known to cause melanomas, basal and squamous cell carcinomas, as well as cataracts and pterygians. Still Australians expose themselves every day to the electro magnetic radiation of this solar systems greatest uncontrolled nuclear reactor. One Australian dies every day from the effects of malignant melanoma and every Australian alive today will develop one of the non melanotic forms of skin cancer.
Freezing with liquid nitrogen is a very effective way to remove a superficial squamous cell carcinoma and even an early basal cell carcinoma. Perhaps the safest remedy remains the removal of tumours under a local aesthetic as a minor surgical procedure. In this way laboratory inspection can confirm the nature and the complete removal of a tumour.
Home Remedies
Vitamin A derivatives have unusual anti skin cancer properties. They can cause regression in pre malignant lesions and have a variable effect on melanotic skin cancers. It is not suggested that people test these effects without the consent and supervision of a qualified medical practitioner. Any bleeding, ulceration, heaping up or expansion of an otherwise harmless sunspot should be viewed at the doctor’s surgery without delay.
*6/131/5*

Droxia (Hydroxyurea)

Tuesday, November 3rd, 2009


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Other names: Hydrea
Droxia (Hydroxyurea)
PROSTATE CANCER
Cancer of the prostate rarely occurs in men before they reach 50 years of age. By the time they reach their eighth decade 60 per cent of men will develop cancer of the prostate.
Obstruction or infection of the urinary tract is common presenting symptoms. Nearly 50 per cent of men present with weight loss, anaemia, bone pain and evidence of secondary spread. At this time a doctor can feel a hard lump at the back of the prostate by digital examination.
Only 20 per cent of men with cancer of the prostate receive curative therapy. This percentage would be much higher if the cancer was caught earlier in the course of the disease. To that end all males over 50 years of age are advised to have a digital examination of the prostate once every year. If it is good enough for the ladies to have a pap smear it is good enough for men to have digital examinations of the prostate.
The Prostate Specific Antigen (PSA) has recently been shown to be elevated in 60 per cent of men with prostatic cancer. There is some suggestion that PSA testing done on its own is a sufficient screening procedure in the detection of cancer of the prostate; but digital examination is also advised.
Home Remedies
Beginning at the age of 50 present for a PSA test and a digital examination of the prostate. Detected early the cure rate for cancer of the prostate is 100 per cent. An enlarged prostate is not considered to be a sign of prostate cancer and it is an inevitable side effect of ageing in the male.
*5/131/5*

Xeloda (Capecitabine)

Tuesday, November 3rd, 2009


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TREATING SKIN CANCER
Skin cancer which is detected early can usually be cured by conservative surgery, requiring only a local anesthetic and day hospitalization. Careful scientific studies over recent years have shown that radical surgery is rarely beneficial. Long gone are the days when all melanomas were removed by extensive surgery, leaving large deformities on the body.
The prognosis for ‘thin melanomas’, that is, those with a thickness of less than one millimeter, is good to excellent, irrespective of the extent of the surgery. ‘Thick melanomas’ have a poor prognosis which is not improved by radical removal.
The best treatment for most skin cancers is complete removal. Radiotherapy is reserved for elderly people or those who cannot tolerate surgery. Certain varieties of basal cell carcinomas can be treated with curettage, liquid nitrogen or laser. In the more advanced stages, melanoma may require additional treatment, such as surgical removal of the lymph nodes, chemotherapy or immunotherapy. Chemotherapy is often rather ineffective, whereas immunotherapy looks promising for certain ‘intermediate’ (between thin and thick) melanomas.
Moh’s microscopically controlled surgery is a relatively new development in the field of skin cancer surgery. Here the skin cancer is removed and checked by frozen section. This allows the cancer to be excised without removing the good skin around it.
Another new development is the use of an injectable drug called Interferon for treating basal cell carcinomas. Most studies demonstrate a high cure rate, without subjecting the patient to surgery. This therapy may turn out to be invaluable for treating skin cancers in cosmetically prominent positions such as the eyelids and nose.
Because we know what causes skin cancer, we can prevent it. As the ozone layer becomes thinner, diligent use of shade and sunscreens becomes even more important. As individuals we need to re-evaluate our current lifestyles and our admiration of sun-bronzed bodies. Sun-bronzed bodies are not ‘healthy’ bodies. There has been a drift in the fashion industry to have models looking much paler, and hopefully this trend will catch on. Parents should encourage their children to avoid overexposure to the sun and to use shade and sunscreens as much as possible.
*8/150/5*

Cytoxan (Cyclophosphamide)

Tuesday, November 3rd, 2009


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Cytoxan (Cyclophosphamide)
TYPES OF SKIN CANCER: MELANOMA
Melanoma is the most feared of the skin cancers occurring in eighteen people out of every 10000. The most common sites of melanoma are the back and legs although they can occur anywhere on the body. If detected early this type of skin cancer can be cured, while late detection will ultimately be fatal, regardless of the treatment.
An early melanoma is usually a painless, two-tone freckle which lies flat on the skin. It is only in the later stages that it becomes raised, itchy and bleeds. Once bleeding occurs, the prognosis is generally poor. Although people are aware of melanoma, they tend to look for the wrong lesion. Most people believe that melanomas are raised and itchy, whereas such lesions are more likely to be innocent moles. Meanwhile, the ’silent’ melanoma goes undetected.
Any two-tone lesion, especially with an area of black spreading into a brown area, should be regarded with suspicion. The outline of a melanoma is irregular, like the map of Australia. They have also been described as looking like ‘a squashed fly’ or ‘chocolate smudged on the skin’. If you suspect a melanoma, you should see a doctor as soon as possible. He or she will confirm the diagnosis by removing the lesion and examining it under a microscope. If a melanoma is detected early, simple, conservative surgery will lead to a total cure. Radical surgery does not improve the prognosis except in more advanced cases, and is becoming increasingly obsolete.
People with very large, irregular moles, called dysplastic naevi, have a greater risk of developing melanoma. They should be checked every six months, using photographs to detect any changes in their moles or any new lesions.
*4/150/5*

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Tuesday, November 3rd, 2009


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Eulexin (Flutamide)
DONЂ™T LET YOUR HEALTH GO UP IN SMOKE: KICKING THE HABIT
Hopefully, some of these facts will help you in your decision to quit. Unfortunately, it will not be easy, and, if you ever pick up a cigarette again, you could well become addicted straight away. What many people fail to realise is that smoking is not simply a nasty ‘habit’, but is in fact an addiction. It is so strong that many people persist in what is clearly one of the most damaging things they can do to their health.
Still, no matter how difficult it may be, take hope! It is possible, with strong willpower, to quit. The best way to do this is to focus on a strategy for quitting, as the fight actually begins before you quit. Start one month before you are going to quit Ђ” set a quitting date, preferably a day with some significance, such as your birthday or Christmas day. The following tips may also help you kick the habit and keep it that way.
When you are tempted to smoke, try squeezing an object such as a rubber ball really hard, as this will promote a temporary increase in both your blood pressure and your pulse, mimicking the increase in these processes which smoking promotes, the absence of which is thought to trigger the urge to smoke. The rise in pulse rate accompanied by smoking, however, is unique in that, unlike more intensive exercise, it stimulates muscle relaxation rather than muscular tension.
Try to strengthen your abdominals or stomach muscles.
This may be the single most important step to take before
actually quitting. If you can contract your abdominal muscles very intensely it will help destroy the craving you experience to draw something into your lungs.
If you experience a craving for a cigarette, why not try to take a drag of clean, fresh air, and hold it in your lungs the way you would do if you were smoking. Have a few trial runs. Pretend that you are going cold turkey, but do so knowing you can resume smoking in 24 hours. Of course, if you can maintain your smoking ban for longer, do so! These dry runs will allow your body to become accustomed to not having smoke continuously inhaled into the lungs.
Men’s Health
CancerAnother useful restriction on your smoking at this stage would be to take only three puffs of a cigarette consecutively. This will slow down your habit without really trying hard. The typical smoker takes about eleven puffs per cigarette, so, even if you need to take more than three puffs in a row, just try to count it down to less than usual. Eventually, you may only need to take one puff per cigarette!
Switch to a low-nicotine brand. Some experts will argue about this, claiming that when a smoker uses a low-nicotine brand, the change simply causes the smoker to inhale more deeply. The idea here is that the tobacco is no different in low-nicotine brands; since the change is in the filter, which is stronger, the smoker will try to compensate by breathing more deeply. Even if this is correct, it should still follow that if you consciously inhale to the same depth as usual, the nicotine content breathed in will be less.
*25/107/2*

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Other names: Abilify
Arimidex (Anastrozole)
EVENING PRIMROSE OIL IN THE TREATMENT OF SCHIZOPHRENIA
There was recently a double-blind trial on Efamol on abnormal movements, psychiatric status and memory on patients with tardive dyskinesia, which showed that evening primrose oil produced significant results in certain aspects of schizophrenia. Memory, and total psychopathology scores improved significantly, and there was a marginal improvement on involuntary abnormal movements.
Tardive dyskinesia (involuntary abnormal movements). Up to 60% of patients on neuroleptic drugs suffer from motor disorders such as tardive dyskinesia as a side-effect. These involuntary abnormal movements are severely disabling and intractable.
In a preliminary study by Dr Vaddadi, it was noticed that there was a sudden reduction in these involuntary movements in some of his schizophrenic patients while they were being treated with evening primrose oil and penicillin. These early findings have been backed up by further studies.
The success of Dr Vaddadi’s work led to a full-scale double-blind trial involving several centres1: the Department of Psychiatry at Crawley Hospital, West Sussex, St George’s Hospital Medical School, London, the Department of Psychology, Middle East Technical University, Ankara, Turkey, and the Efamol Research Institute in Kentville, Nova Scotia, Canada. As well as researching the effects of evening primrose oil on tardive dyskinesia, they also looked at the oil’s effects on psychiatric status, and on memory.
The trial involved 48 psychiatric patients with established movement disorders who had been on neuroleptic drugs over a long period of time. Thirty-nine of these patients were schizophrenic, four manic-depressive, and three had personality disorders. All of them had involuntary abnormal movements of at least mild severity. Patients were kept on their existing medication, and were matched against controls.
The patients were given either Efamol, or a placebo, for 16 weeks. The dose was 12 capsules of Efamol (or a placebo) divided up over the day. At the end of the 16 week period, there was a cross-over, so that the patients who had been on the Efamol received the placebo instead, and vice versa.
Assessments were made at the beginning of the trial and then at two-weekly intervals throughout the trial. Blood samples were also collected and analyzed.
The results of these blood tests showed that all psychiatric patients had below-normal levels of essential fatty acids. Patients with severe tardive dyskinesia had the lowest levels – significantly lower than both the patients without any movement disorder, and also those with only mild movement disorder.
This shows that there is an association between low levels of essential fatty acids, and the presence and severity of tardive dyskinesia. There is also a close association between low levels of essential fatty acids and psychosis. Giving supplements of essential fatty acids to these patients produced a move towards normal in their red cell membranes, but they did not reach normal levels.
The overall results of this trial on tardive dyskinesia showed a small but significant improvement with Efamol. However, this study on human psychiatric patients was not as convincing as previous animal experiments which had shown that essential fatty acids do have a noticeable effect on abnormal movements.
Perhaps the reason why this trial had slightly disappointing results was because there are irreversible structural changes to the brain in patients with severe and prolonged movement disorders; perhaps the dose was too low and the treatment period too short. There may also be a problem with absorbing essential fatty acids; it probably takes much longer to correct abnormal levels of essential fatty acids in the brain, than in red blood cells. Further research is planned to see whether the results could be more positive with a higher dose over a longer treatment period.
Even though the results of this trial were only marginally significant for the role of evening primrose oil in tardive dyskinesia, it is still worthwhile giving supplements of evening primrose oil, together with neuroleptic drugs, in the prevention and management of this disease.
Memory and psychiatric status. The effect of Efamol as an antipsychotic and as an improver of memory in tests was much more pronounced than its effects on tardive dyskinesia.
There was a mean improvement of 20% to 30% in the psychopathology scores at the end of the treatment with evening primrose oil. This improvement occurred in chronic patients with schizophrenia for whom orthodox neuroleptic therapy had little to offer. This related especially to the ‘negative’ symptoms of schizophrenia, such as ‘flat’ emotions and social withdrawal.
With memory, there was a clear deterioration when patients switched from active treatment to placebo. Other studies have shown that Efamol improves cerebral function to a significantly greater degree than a placebo.
*39/60/5*

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ACNE: ENDING BREAKOUTS ISNЂ™T HARD TO DO
So you woke up this morning with a zit in the middle of your forehead. What do you do now?
Well, you could bravely venture forth, looking upon this as an exercise in humility, a chance to prove that you can transcend the merely physical. Or you could cancel all your appointments, pull the blinds and pray that this epidermal abomination disappears as quickly as it arrived.
Whichever course you choose, you’re likely to wonder why your acne didn’t disappear with your youth the way it was supposed to. The answer is fairly simple.
Men’s Health
CancerYour complexion goes bonkers during puberty because male hormones stimulate the production of the skin’s lubricating oil. As you get older, your hormones settle down, but they don’t disappear entirely, and neither may your acne. But fortunately, for most men acne is just a faded memory. Only between 5 and 10 percent of men over 25 still do regular battle with acne.
Despite the myth that chocolate or greasy foods are the cause of adult acne, doctors now believe heredity overwhelmingly dictates whether or not your pores have a tendency to clog.
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PREVENTING SKIN CANCER: STAYING INDOORS, PHYSICAL SHADE AND SUNSCREENS
Ultraviolet ’ light is strongest in summer and in the middle of the day (10.00 a.m. to 3.00 p.m.). It penetrates through clouds and fifty per cent penetrates through water. In addition, about eighty-five per cent reflects off surfaces such as snow, concrete and sand. It is, however, almost totally blocked by windows, glass and perspex. There are a number of things we can do to protect ourselves from the harmful effects of sunlight.
Stay indoors
It is best to stay indoors during the middle of the day when the ultraviolet light is at its most intense. Children should be encouraged to play outdoors only in the early morning or late in the afternoon. It is also best to schedule tennis and other sporting activities for these times.
Physical shade
Shade can be created safely and inexpensively with careful planning. Natural sun protection can be created by such things as trees, roofs and pergolas which can easily be used around swimming pools and playgrounds.
Wide-brimmed hats should be worn outdoors. To effectively protect you from the sun a hat must have a five-centimeter brim and should be made of tightly woven materialЂ”when you hold it up to the sun you should not be able to see through it. Clothing also provides excellent protection from the sun. Again, tightly woven fabrics are best. If you swim in a T-shirt, you should change into a dry one when you come out of the water.
Physical sunscreens
Shade will not protect you from sun which reflects off sand, snow and concrete. Sunscreens are therefore necessary for areas such as the face and hands. Physical sunscreens which contain zinc or titanium dioxide are best as they completely block out both ultraviolet A and ultraviolet ’ light and are nontoxic and non-irritating. The main drawbacks of physical sunscreens are that they may not look very attractive and they tend to stain clothing.
Physical sunscreens have been available for over fifty years in the form of stage make-up and zinc creams. Indeed, the old-fashioned, thick, pancake make-ups are still the best sunscreens available as they block out all ultraviolet rays and stay on for many hours. Other good sunscreen make-ups include Clinique Continuous Coverage, Dermablend and Dermacolor. Recently florescent zinc creams have become very popular. They are effective sunscreens and are fun for children but are extremely difficult to wash out of clothing.
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