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HORMONES: STUDIES AND RESEARCHES
In 1983, Ruby Hunt-Russell of Torrance, California, was born without a thyroid gland. Had she come into the world 4 years earlier, the lack of thyroid hormones would have irrevocably damaged her brain. But she was lucky. In 1980, California implemented a law requiring that every newborn get a thyroid test. Today, most states have such a law.
When Ruby was 2 days old, doctors took a sample of her blood. No thyroid hormone showed in the sample. X rays of the base of her throat, the site of the thyroid, revealed no thyroid gland. In this country, one baby in 4,000 is born with a defective thyroid or is lacking one. Doctors prescribed that thyroxin be given to Ruby in her milk. She will take the hormone in pill form for the rest of her life.
“She is totally normal, physically and in intelligence,” says Lyn Hunt-Russell, Ruby’s mother, a schoolteacher.
Ruby today is a striking blond child, with giant brown eyes and a California tan. Without thyroid hormone, she would have become a mentally retarded dwarf.
Scientists also have learned that glands strongly influence both your physical life and your moods and thoughts. Too much or too little hormone secretion by glands can cause anxiety (nonstop fear or depression) and uncontrollable sadness and moroseness, or impair the ability to think clearly.
More news: Other organs, in addition to your glands, make important hormones. Your kidneys make erythropoietin, a substance that spurs the growth of red blood cells. Scientists have made this hormone artificially to help produce blood in people without kidneys.
Your heart pours out atrial natriuretic factor, a hormone that controls blood pressure. Some doctors believe this hormone may be the most powerful medicine yet discovered for high blood pressure. Your stomach secretes cholecystokinin, which tells your brain that you have had enough to eat. If scientists can find ways of making this substance in quantity, they may have the drug that will end the need for dieting forever.
The new knowledge about hormones has given doctors powerful new treatments for ailments that had resisted cure. Among them are synthetic growth hormone to make dwarfs grow to near normal height, tests to show whether depression has a glandular cause, hormone techniques to treat infertility, and hormone treatments for menopause symptoms.
They also have found inhibin, a hormone that could be a male contraceptive. Inhibin is made by the testes and ovaries. But its commercial production for general use could be years off.
At the Salk Institute in La Jolla, California, Dr. Roger Guillemin, a Nobel Prize winner, and his colleagues have isolated what Dr. Guillemin calls “perhaps the most important molecule ever characterized.” Called fibroblast growth factor (FGF), it speeds up the healing of wounds, stimulates the growth of new blood vessels after menstruation, and helps restore damaged nerves. It may be involved in stimulating blood vessel growth to feed new blood to the heart after a heart attack or to the brain after a stroke.
Scientists are trying to create FGF by genetic engineering as a possible treatment for heart attack or stroke patients.
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