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NUTRIENTS FOR YOUR BODY: FOLACIN AS A WATER-SOLUBLE VITAMIN
Functions
Folacin, like other В vitamins, is a component of specific enzymes. These are required for the formation of DNA and heme in the red blood cells, and for the metabolism of specific amino acids. Although both folacin and vitamin B12 are needed for the formation of red blood cells, one cannot replace the other.
Meeting daily needs
The recommended allowance of folacin is 400 mcg for adults and 100 to 300 mcg. for children.
The word “folacin” is derived from folium meaning green leaf. Thus, green, leafy vegetables are a good source. Other good sources include organ meats, meat, poultry, fish, and whole-grain cereals. Folacin is rapidly destroyed in prolonged cooking, with high temperatures as used in food processing, and with prolonged storage periods.
Clinical problems
Folacin deficiency is relatively uncommon. It does occur because of (1) lack in the diet, or (2) failure to absorb folacin in diseases of malabsorption, especially sprue. The principal characteristic of folacin deficiency is a macrocytic anemia. A sore mouth and diarrhea are often present.
During pregnancy a macrocytic anemia because of folacin deficiency is sometimes observed. Apparently the folacin needs of the fetus are high. Elderly persons who have had a diet low in folacin for a long period of time sometimes have a folacin deficiency.
The absorption of folacin is reduced in alcoholism, and with the use of anti-tubercular drugs and some anticonvulsants. Contraceptives also increase the requirement for folacin. Methotrexate, a powerful antitumor treatment, is also an antagonist to folacin.
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