Mestinon (Pyridostigmine)
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| medixresources | Not available for sale | 14/free |      | most countries | |
| tl-pharmacy "Generic Mestinon" | 60mg | 10-21 days/free |    | every country | |
| 30 pills €73.41 | 180 pills €316.58 | ||||
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| medrx-one "Generic Mestinon" | 60mg | 10 days/free | | most countries | |
| 30 pills $97.2 | 180 pills $419.2 | ||||
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| leadmedic "Mestinon" | 60 mg | 14-21days/$10
5-7 days/$25 | | every country | |
| 30 pills $102.72 | 90 pills $229.12 | ||||
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| Medph | Not available for sale | FedEx next day/$24 |  | USA only | |
| med-pen "Mestinon" | 60mg | 14-20 days/$10
7-14 days/$20 |   | most countries | |
| 60 Tabs $132 | 480 Tabs $792.06 | ||||
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| ourpharmacyrx "Mestinon" | 60 mg | 14-21 days/$15
5-12 days/$30 | | most countries | |
| 30 pills $99 | 180 pills $450 | ||||
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| RxPharms | Not available for sale | 14-24 days/free | | worldwide | |
| RxMedShop | Not available for sale | 8-16 days/$20
5-9 days/$30 3-6 days/$40 | | most countries | |
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EVENING PRIMROSE OIL AND ALCOHOLISM
Evening primrose oil has proved to be very useful in treating certain aspects of alcoholism, particularly withdrawal symptoms, liver damage, and hangovers. It may also help reverse some of the brain damage caused by alcoholism.
The reason why evening primrose oil works in alcoholism is largely because it converts to Prostaglandin El (PGE1). This prostaglandin plays a key role in alcoholism.
Alcohol has a paradoxical effect on PGEl. When you drink small amounts of alcohol, it stimulates the production of PGEl. But when the level of drinking is stepped up, alcohol robs the body of PGEl.
In fact, small amounts of alcohol may be positively good for you. Recent research in North America and Western Europe has consistently reached this conclusion. The risk of heart disease is reduced in people who have a modest intake of alcohol – perhaps a glass or two of wine, or a beer, or one or two drinks of whisky a day. People who drink at this level tend to live longer than teetotalers, and much longer than people who drink more alcohol.
Many people drink socially because it makes them feel good. This may well be because, without knowing it, they are raising their levels of PGEl. PGEl can bring about euphoric states: doctors have noticed almost euphoric reactions in patients being given intra-venous infusion of PGEl. And studies on manic people, who feel abnormally euphoric, show that they make more PGE1 than normal. However, this mood-elevating effect of PGE1 from drinking alcohol only happens when someone drinks small amounts.
The story changes quite dramatically once the intake of alcohol increases to moderate or large amounts. At this level, alcohol has two bad effects on the body’s stores of essential fatty acids, and therefore on the metabolism of prostaglandin El.
First, alcohol enhances the conversion of dihomo-gammalinolenic acid to PGE1. This may sound like a good thing, but in fact it has disastrous consequences. Because alcohol stimulates the synthesis of PGE1, it draws on the body’s stores of dihomo-gammalinolenic acid (DGLA), and these stores of DGLA can run out quite quickly. When the action of the alcohol wears off, the stores of DGLA may be so reduced that the levels of PGE1 fall below normal.
Second, alcohol in moderate to large amounts is one of the main blocking agents in the metabolic pathway of essential fatty acids. Alcohol blocks both the delta-6-desaturase enzyme, and also the delta-5-desaturase enzyme. The delta-6-desaturase enzyme converts linoleic acid to GLA, and the delta-5-desaturase enzyme converts DGLA to arachidonic acid. These two enzymes are also involved in the metabolism of the alpha-linolenic acid family, and alcohol blocks the metabolic pathway of this family of essential fatty acids as well. Incidentally, alcohol has no effect on these enzymes if it is only drunk in small amounts.
The consequences of these two things are serious. As alcohol blocks the conversion of linoleic acid to GLA, this also has an effect on the stores of DGLA. It means that no matter how much linoleic acid you eat in your diet, the depleted stores of DGLA cannot be replenished. Consequently, drinking moderate to large amounts of alcohol over a long period of time will lead to a serious deficiency of essential fatty acids.
Many of the long-term effects of alcohol may relate to these very low levels of essential fatty acids. The dramatic fall in PGE1 which happens in alcoholism may account for the hangovers, withdrawal symptoms and depression that so often go with heavy drinking.
The low levels of PGE1 in alcoholics may have other serious consequences too. This includes the risk of heart attacks and strokes, high blood pressure, a reduced ability to cope with infections, brain and nerve deterioration, and liver damage. An alcoholic gets caught in a vicious spiral. He or she may have started drinking because it gave his or her mood a lift-But the more he or she drinks, the more he or she needs to drink to get the same ‘high’. The explanation for this is that as you drink more and more, your supplies of dihomo-gammalinolenic acid get lower and lower, so PGE1 simply cannot be made.
*34/60/5*
