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WORLD WITHOUT DISEASE: GENETIC COUNSELING
Because they know the genetic formulas for several genes, scientists can hunt down and diagnose certain genetic abnormalities in the tissues of the human body.
Doctors already screen for genetic defects prenatally (i.e., before birth) thanks to amniocentesis. In the diagnostic procedure, the doctor removes a sample of amniotic fluid from the mother’s womb, into which cells from the fetus have been shed. He then checks these cells for genetic defects.
One day, doctors will routinely screen adults to see whether they carry faulty genes. They also will be able to detect a person’s susceptibility to certain diseases such as hardening of the arteries, gout, and diabetes, even though the illness may not develop until years later.
At the University of California, Irvine, Drs. G. Wesley Hatfield and Moyra Smith recently cloned three different genes that mutate in certain people, which prevent the proper metabolism of alcohol. If pregnant women have this problem, even small amounts of alcohol will cause severe developmental defects in the unborn child, a condition known as fetal alcohol syndrome.
Doctors also hope to replace missing genes. One way to insert a missing gene is to splice it into the genes of a virus. The virus infects all the body cells and drops the missing gene into them.
Splicing genes into viruses is also being used to make vaccines. Scientists at the New York State Department of Health used this technique, which is also known as gene transfer, to make experimental vaccines against herpes and hepatitis viruses.
To make a herpes vaccine, for example, they isolated a gene from a herpes virus. They transferred that gene into a harmless virus called vaccinia. The vaccinia then “looked” enough like the herpes virus to stimulate the production of antibodies against herpes. When the vaccinated person later was exposed to a real herpes virus, he was protected by those antibodies. The scientists used the same technique to create the hepatitis vaccine.
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